Asllani NeuroImaging Lab
Cerebral Perfusion, Physiological MRI, and Brain–Heart Interactions
Research Overview
Our research focuses on understanding how brain function is shaped by its underlying physiology, with a particular emphasis on cerebral blood flow (CBF), vascular dynamics, and their interaction with systemic processes such as cardiac function. Using arterial spin labelling (ASL) MRI and complementary physiological imaging techniques, we study how perfusion supports neural activity across a range of contexts, from cognitive and affective processes to clinical and physiological challenges.
A central aim of the lab is to move beyond static or isolated measures of brain function toward a more integrated framework in which neural, vascular, and systemic signals are considered jointly. More recently, this has extended to investigating brain–heart interactions, including how cardiac oscillations and autonomic dynamics influence cerebral perfusion and brain function.
Alongside these scientific questions, we place strong emphasis on methodological development. This includes designing and implementing new analysis approaches for ASL and physiological MRI data, improving robustness and interpretability, and developing tools that can be deployed across diverse research environments, including settings where access to advanced infrastructure may be limited.
Through this work, we aim to contribute both to fundamental understanding of brain physiology and to the development of scalable, reproducible imaging approaches that can support research and training in a global context.
Key Research Questions
- How does CBF support and constrain neural function across cognitive, affective, and physiological states?
- How do systemic physiological processes, particularly cardiac dynamics, interact with brain perfusion and metabolism?
- Can brain–heart interactions provide novel biomarkers of neurological and psychiatric conditions?
- How can ASL and physiological MRI methods be optimized for robustness, reproducibility, and broader accessibility?
- What methodological advances are needed to enable high-quality imaging research in resource-variable settings?
Research Approaches / Technologies
- Arterial Spin Labelling (ASL) MRI for quantitative CBF measurement
- Physiological MRI and multimodal integration
- Development of robust, scalable neuroimaging workflows
- Integration of imaging with behavioral and physiological paradigms
Collaboration and Capacity Building
The lab is actively engaged in international collaborations spanning Europe, Africa, and North America, with a strong commitment to capacity building in neuroimaging. This includes training students and researchers, developing accessible analysis tools, and supporting the establishment of sustainable imaging research programs.
A key priority is to ensure that participation in MRI research is not constrained by limited local access to scanning infrastructure. While data acquisition can be performed at partner sites, the majority of the research process—experimental design, data processing, analysis, and interpretation—can be conducted locally. This approach allows students to engage directly with real datasets, develop robust analytical skills, and contribute meaningfully to research projects without requiring on-site MRI facilities.